CovidV2, Main, Exploration, bibRecord, 001E96

Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats

Identifieur interne : 001E96 ( Main/Exploration ); précédent : 001E95; suivant : 001E97

Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats

Auteurs : K. Nagashima [Allemagne] ; H. Wege [Allemagne] ; R. Meyermann [Allemagne] ; V. Ter Meulen [Allemagne]

Source :

Acta Neuropathologica [ 0001-6322 ] ; 1979-01-01.

RBID : ISTEX:893A3708A5B07785EA0E3694B68A9E8274262348

Descripteurs français

KwdFr :
- Animaux, Antigènes viraux (analyse), Encéphalomyélite (étiologie), Facteurs temps, Infections à Coronaviridae (), Maladie chronique, Maladies démyélinisantes (étiologie), Rats, Récidive.
MESH :
- analyse : Antigènes viraux.
- étiologie : Encéphalomyélite, Maladies démyélinisantes.
- Animaux, Facteurs temps, Infections à Coronaviridae, Maladie chronique, Rats, Récidive.

English descriptors

KwdEn :
- Animals, Antigens, Viral (analysis), Chronic Disease, Corona virus rats, Coronaviridae Infections (complications), Demyelinating Diseases (etiology), Encephalomyelitis (etiology), Late onset demyelination, Multiple sclerosis, Rats, Recurrence, Remyelination, Time Factors.
MESH :
- chemical , analysis : Antigens, Viral.
- complications : Coronaviridae Infections.
- etiology : Demyelinating Diseases, Encephalomyelitis.
Teeft :
- Acta, Acta neuropathol, Allergic encephalomyelitis, Animal model, Animals, Astrocytic processes, Axon, Basement membrane, Brain suspension, Chronic Disease, Chronic relapsing, Clinical signs, Control animals, Corona, Corona virus, Demyelinated areas, Demyelinating, Demyelinating encephalomyelitis, Demyelinating lesions, Demyelinating plaques, Demyelination, Disease process, Electron microscopy, Encephalomyelitis, Federal republic, Glial, Glial cells, Incubation period, Inoculation, Intracerebral inoculation, Late onset, Lesion, Light microscopy, Long incubation period, Lower part, Mononuclear cells, Mouse hepatitis virus, Multiple sclerosis, Murine corona virus, Myelin, Myelin sheaths, Nagashima, Naked axon, Naked axons, Neurological signs, Neuropathol, Optic nerve, Optic tract, Peripheral myelin, Peripheral nerves, Plaque, Present study, Rats, Recurrence, Remyelinated areas, Remyelination, Schwann, Schwann cell, Schwann cells, Sclerosis, Sheath, Small cells, Spinal, Spinal cord, Spinal tract, Subacute demyelinating encephalomyelitis, Time Factors, Trigeminal, Trigeminal nerve, Trigeminal nerves, Ultrastructural study, Upper corner, Vesicular disruption, Viral antigen, Virus inoculation, Weanling rats, White matter.

Abstract

Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.

Url:

DOI: 10.1007/BF00702672

Affiliations:

Allemagne

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<front><div type="abstract" xml:lang="en">Summary: About 30% of weanling rats inoculated with JHM virus developed a subacute demyelinating encephalomyelitis (SDE) 3 weeks after inoculation (a.i.). From the remaining animals, 5% displayed overt neurological signs 3,6, and 8 months a.i. Animals with and without clinical signs 6–8 months a.i. were morphologically examined. Fresh demyelinating lesions could be demonstrated in paralyzed animals. Viral antigen was demonstrated and infectious JHM virus could be recovered from one animal which developed clinical signs at 3 months a.i. In one animal with clinical onset of 8 months a.i., completely remyelinated areas as well as recent demyelinating lesions were observed, suggesting a recurrence of the disease process. Remyelinated areas were also found in 40% of clinically silent animals. The morphology of the late onset of the demyelination was similar to that occurring in SDE. Remyelination consisted of both CNS and PNS-type. This animal model offers the possibility to investigate the virus-host relationship which is responsible for the induction of a demyelinating process after a long incubation period.</div>
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Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats

Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration Covid (26 mars)
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